2013年

Seki F, Hikishima K, Nambu S, Okanoya K, Okano HJ, Sasaki E, Miura K, Okano H. Multidimensional MRI-CT atlas of the naked mole-rat brain (Heterocephalus glaber). Front Neuroanat. 2013 Dec 20;7:45. [PubMed]

Okano H. Regenerative medicine of central and peripheral nervous system. Rinsho Shinkeigaku. 2013;53(11):1124. [PubMed]

Nakamura M, Toyama Y, Okano H. Current status and perspective on regenerative medicine for spinal cord injury using iPS cell. Rinsho Shinkeigaku. 2013;53(11):1013-5. [PubMed]

Imaizumi Y, Okano H. Modeling human neurological disorders with induced pluripotent stem cells. J Neurochem. 2013 Nov 29. doi: 10.1111 [PubMed]

Nakamura M, Okano H, Toyama Y. [110th Scientific Meeting of the Japanese Society of Internal Medicine: Symposium: 1. Frontier of the regenerative medicine; 4) Perspective on regenerative medicine for spinal cord injury using iPS cell–from bench to bedside]. Nihon Naika Gakkai Zasshi. 2013 Sep 10;102(9):2247-53. [PubMed]

Ohyama M, Okano H. Promise of Human Induced Pluripotent Stem Cells in Skin Regeneration and Investigation. J Invest Dermatol. 2014 Mar;134(3):605-9. doi: 10.1038 [PubMed]

Horiuchi Y, Kano SI, Ishizuka K, Cascella NG, Ishii S, Jr CC, Jaffe AE, Okano H, Pevsner J, Colantuoni C, Sawa A. Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: Utility and limitation of the surrogate tissues in research for brain disorders. Neurosci Res. 2013 Dec;77(4):247-50. doi: 10.1016 [PubMed]

Shinozaki M, Nakamura M, Konomi T, Kobayashi Y, Takano M, Saito N, Toyama Y, Okano H. Distinct roles of endogenous vascular endothelial factor receptor 1 and 2 in neural protection after spinal cord injury. Neurosci Res. 2014 Jan;78:55-64. doi: 10.1016/j.neures.2013.09.011. Epub  2013 Oct 6. [PubMed]

Shinozaki M, Yasuda A, Nori S, Saito N, Toyama Y, Okano H, Nakamura M. Novel Method for Analyzing Locomotor Ability After Spinal Cord Injury in Rats: Technical Note. Neurol Med Chir (Tokyo).  2013 Dec 25;53(12):907-13. Epub  2013 Oct 7. [PubMed]

Sasaki T, Shiohama A, Kubo A, Kawasaki H, Ishida-Yamamoto A, Yamada T, Hachiya T, Shimizu A, Okano H, Kudoh J, Amagai M. A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis. J Allergy Clin Immunol. 2013 Sep 20. pii: S0091-6749(13)01341-9. [PubMed]

Ohta S, Misawa A, Lefebvre V, Okano H, Kawakami Y, Toda M. Sox6 up-regulation by macrophage migration inhibitory factor promotes survival and maintenance of mouse neural stem/progenitor cells. PLoS One. 2013 Sep 16;8(9):e74315. [PubMed]

Mabuchi Y, Morikawa S, Harada S, Niibe K, Suzuki S, Renault-Mihara F, Houlihan DD, Akazawa C, Okano H, Matsuzaki Y.LNGFR(+)THY-1(+)VCAM-1(hi+) Cells Reveal Functionally Distinct Subpopulations in Mesenchymal Stem Cells. Stem Cell Reports.  11;1(2):152-65, 2013. doi: 10.1016 [PubMed]

Iwai H, Nori S, Nishimura S, Yasuda A, Takano M, Tsuji O, Fujiyoshi K, Toayama Y, Okano H, Nakamura M. Transplantation of neural stem/progenitor cells at different locations in mice with spinal cord injury. Cell Transplant.  [Epub ahead of print] 【PubMed】

Imamura M, Hikabe O, Lin ZY, Okano H.Generation of germ cells in vitro in the era of induced pluripotent stem cells.Mol Reprod Dev. doi: 10.1002 , 2013【PubMed】

Nishimoto Y, Nakagawa S, Hirose T, Okano HJ, Takao M, Shibata S, Suyama S, Kuwako K, Imai T, Murayama S, Suzuki N, Okano H. The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis. Mol Brain.  Jul 8;6(1):31 2013 [PubMed]

Sato H, Shibata M, Shimizu T, Shibata S, Toriumi H, Ebine T, Kuroi T, Iwashita T, Funakubo M, Kayama Y, Akazawa C, Wajima K, Nakagawa T, Okano H, Suzuki N.Differential cellular localization of antioxidant enzymes in the trigeminal ganglion. Neuroscience. pii: S0306-4522(13)00507-1. doi: 10.1016/j.neuroscience.2013 [PubMed]

Mabuchi Y, Houlihan DD, Akazawa C, Okano H, Matsuzaki Y.Prospective isolation of murine and human bone marrow mesenchymal stem cells based on surface markers. Stem Cells Int.  doi: 10.1155/2013/507301.  2013. [PubMed]

Morizane R, Monkawa T, Fujii S, Yamaguchi S, Homma K, Matsuzaki Y, Okano H, Itoh H.Kidney specific protein-positive cells derived from embryonic stem cells reproduce tubular structures in vitro and differentiate into renal tubular cells.PLoS One.2013 Jun 3;8(6):e64843. doi: 10.1371 [PubMed]

Natsume A, Ito M, Katsushima K, Ohka F, Hatanaka A, Shinjo K, Sato S, Takahashi S, Ishikawa Y, Takeuchi I, Shimogawa H, Uesugi M, Okano H, Kim SU, Wakabayashi T, Issa JP, Sekido Y, Kondo Y. Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma.Cancer Res. 2013 May 29. [PubMed]

Wang XY, Yu H, Linnoila RI, Li L, Li D, Mo B, Okano H, Penalva LO, Glazer RI. Musashi1 as a potential therapeutic target and diagnostic marker for lung cancer. Oncotarget. 4(5):739-50 2013. [PubMed]

Lin CH, Lee HT, Lee SD, Lee W, Cho CW, Lin SZ, Wang HJ, Okano H, Su CY, Yu YL, Hsu CY, Shyu WC.Role of HIF-1α-activated Epac1 on HSC-mediated neuroplasticity in stroke model.Neurobiol Dis. doi: 10.1016 ,2013.  [PubMed]

Muto J, Imai T, Ogawa D, Nishimoto Y, Okada Y, Mabuchi Y, Kawase T, Iwanami A, Mischel PS, Saya H, Yoshida K, Matsuzaki Y, Okano H. RNA-Binding Protein Musashi1 Modulates Glioma Cell Growth through the Post-Transcriptional Regulation of Notch and PI3 Kinase/Akt Signaling Pathways.PLoS One. 25;8(4),2013. doi: 10.1371 [PubMed]

Fukuda T, Takeda S, Xu R, Ochi H, Sunamura S, Sato T, Shibata  S, Yoshida Y, Gu Z,Kimura A, Ma C, Xu C, Bando W, Fujita K, Shinomiya K, Hirai T, Asou Y, Enomoto M,Okano H, Okawa A, Itoh H.:Sema3A regulates bone-mass accrual through sensory innervations. Nature. 2013 May 5. doi: 10.1038/nature12115. corrigendum ; 2013 Aug 7. [PubMed]

Higurashi N, Uchida T, Christoph L, Misumi Y, Okada Y, Akamatsu W, Imaizumi Y, Zhang B, Nabeshima K, Mori MX, Katsurabayashi S, Shirasaka Y, Okano H, Hirose S.:A human Dravet syndrome model from patient induced pluripotent stem cells. Mol Brain. 2;6(1):19,2013 [PubMed]

Ohtomo R, Mori T, Shibata S, Tsuta K, Maeshima AM, Akazawa C, Watabe Y, Honda K, Yamada T, Yoshimoto S, Asai M, Okano H, Kanai Y, Tsuda H.: SOX10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors: a clue to the histogenesis for tumor diagnosis. Mod Pathol. 2013 Apr 5.[PubMed]

Nihei Y, Ito D, Okada Y, Akamatsu W, Yagi T, Yoshizaki T, Okano H, Suzuki N. Enhanced aggregation of androgen receptor in induced pluripotent stem cell-derived neurons from spinal and bulbar muscular atrophy. J Biol Chem. 2013 Mar 22;288(12):8043-52 [PubMed]

Tatsumoto S, Adati N, Tohtoki Y, Sakaki Y, Boroviak T, Habu S, Okano H, Suemizu H, Sasaki E, Satake M. Development and Characterization of cDNA Resources for the Common Marmoset: One of the Experimental Primate Models. DNA Res. 2013 Mar 29.[PubMed]

Nitta M, Imamura M, Inoue Y, Kunitomo Y, Lin ZY, Ogawa T, Yogo K, Ishida-Kitagawa N, Fukunaga N, Okano H, Sato E, Takeya T, Miyoshi J. Aberrant Gene Expression and Sexually Incompatible Genomic Imprinting in Oocytes Derived from XY Mouse Embryonic Stem Cells In Vitro. PLoS One. 8(3):e58555, 2013.[PubMed]

Ohta S, Imaizumi Y, Akamatsu W, Okano H, Kawakami Y. Generation of humanmelanocytes from induced pluripotent stem cells. Methods Mol Biol. 989: 193-215, 2013.[PubMed]

Kanda H, Nguyen A, Chen L, Okano H, and Hariharan I.: The Drosophila ortholog of MLL 3/MLL 4, trithorax related, functions as a negative regulator of tissue growth. Mol. Cell Biol, 33(9):1702-1710,2013. [PubMed]

Takahashi T, Suzuki H, Imai T, Shibata S, Tabuchi Y, Tsuchimoto K, Okano H, Hibi T.: Musashi-1 post-transcriptionally enhances phosphotyrosine-binding domain-containing m-Numb protein expression in regenerating gastric mucosa. PLoS ONE,8(1):e53540,2013.[PubMed]

Hirata A, Utikal J, Yamashita S, Aoki H, Watanabe A, Yamamoto T, Okano H, Bardeesy N, Kunisada T, Ushijima T, Hara A, Jaenisch R, Hochedlinger K, Yamada Y.: Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium. Development. 140(1):66-75, 2013. [PubMed]

Nishimura S, Yasuda A, Iwai H, Takano M, Kobayashi Y, Nori S, Tsuji O, Fujiyoshi K, Takahashi Y, Ebise H, Toyama Y, Okano H , Nakamura M.: Time-dependent changes in the microenvironment of injured spinal cord affects the therapeutic potential of neural stem cell transplantation for spinal cord injury. Mol. Brain, 6:3, 2013.[PubMed]

Mizutari K, Fujioka M, Hosoya M, Bramhall N, Okano HJ, Okano H, Edge ASB. : Notch inhibition induces cochlear hair cell regeneration and recovery from noise-induced hearing loss. Neuron,77(1):58-69, 2013.[PubMed]

Imai S, Ikegami D, Yamashita A, Shimizu T, Narita M, Niikura K, Furuya M, Kobayashi Y, Miyashita K, Okutsu D, Kato A, Nakamura A, Araki A, Omi K, Nakamura M, Okano HJ, Okano H, Ando T, Takeshima H, Ushijima T, Kuzumaki N, Suzuki T and Narita M. Epigenetic transcriptional activation of MCP-3 contributes to long-lasting neuropathic pain. Brain, 136(Pt 3):828-43, 2013.[PubMed]

Nishimoto Y, Okano HJ, Imai T, Poole AJ, Suzuki N, Keirstead H , Okano H:Cellular toxicity induced by the 26-kDa fragment and amyotrophic lateral sclerosis-associated mutant forms of TAR DNA-binding protein 43 in human embryonic stem cell-derived motor neurons. Neurology and Clinical Neuroscience,  24-31, 2013.[Neurology and Clinical Neuroscience]

Veraitch O, Kobayashi T, Imaizumi Y, Akamatsu W, Sasaki T, Yamanaka S, Amagai M, Okano H and Ohyama M1: Human induced pluripotent stem cell-derived ectodermal precursor cells contribute to hair follicle morphogenesis in vivo. Journal of Investigative Dermatology, doi: 10.1038, 2013.[PubMed]

Shofuda T, Kanematsu D, Fukusumi, H, Yamamoto A, Bamba Y, Yoshitatsu S, Suemizu H, Nakamura M, Sugimoto Y, Kusuda Furue M, Kohara A, Akamatsu W, Okada Y, Okano H, Yamasaki M and Kanemura Y. :Human Decidua-Derived Mesenchymal Cells Are a Promising Source for the Generation and Cell Banking of Human Induced Pluripotent Stem Cells Cell Medicine  Vol. 4, pp. 125–147, 2013.

Nakamura M, Okano H: Cell transplantation for spinal cord injury focusing on induced pluripotent stem cells. Cell Res. 23(1):70-80, 2013.[PubMed]

Okano H, Nakamura M, Yoshida K, Okada Y, Tsuji O, Nori S, Ikeda E, Yamanaka S, Miura K.: Steps toward safe cell therapy using induced pluripotent stem cells. Circulation Research, 112(3):523-33, 2013.[PubMed]

Iwanami A, Gini B, Zanca C, Matsutani T, Assuncao A, Nael A, Dang J, Yang H, Zhu S, Kohyama J, Kitabayashi I, Cavenee WK, Cloughesy TF, Furnari FB, Nakamura M, Toyama Y, Okano H, Mischel PS. : PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies. Proc Natl Acad Sci USA. 110(11):4339-4344,2013.[PubMed]